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Basic and Clinical Aspects of Neuroendocrine Immunology in Rheumatic Diseases





95.40€
ISBN - 9781573315937
Autor(es) - Maurizio Cutolo, J.W.J. Bijlsma, Alfonse Masi, Rainer Straub
Editora - John Wiley
Ano de Edição - 2006
N º de Páginas - 382


Description

Neuroimmunoendocrine aspects of the pathophysiology of rheumatic diseases are presented in this volume, and new approaches to diagnosis and therapeutic intervention are suggested.

Topics presented include gene polymorphisms and the neuroendocrine immune system in rheumatic diseases, anti-TNF strategies and effects on neuroendocrine immune mechanisms in rheumatic diseases, new perspectives on therapeutic use of glucocorticoids, nerve fibers and rheumatoid arthritis, stimulation tests of the stress axes, and sex hormones and lipid metabolism in rheumatic diseases.


Table of Contents

Introduction: The Neuro Endocrine Immune System Involvement in Rheumatology:

Part I: The Role of Genetics: Gene Polymorphisms and the Neuroendocrine Immune System in Rheumatic Diseases
1. Corticotropin - releasing Hormone promoter Polymorphism - What is the Reality
2. The Glucocorticoid receptor
3. ACE Polymorphism and Scleroderma
4. Genetic variations in the endothelin system: do polymorphisms affect therapeutic strategies?

Part II: The Central Nervous System: Stimulation tests of the Stress Axes and its involvement in Rheumatic Diseases
5. Stress tests in arthritic animals
6. Stress system activity, innate pro - and anti -inflammatory Cytokines and susceptibility to Immune-related Diseases
7. Stress tests in adults with Rheumatic Diseases
8. Hypoglycemia and the sympathetic nervous response
9. Increased neural sympathetic activation in fibromyalgia syndrome
10. Autoantibody profile in systemic lupus erythematosus with psychiatric manifestations: a role for anti-endothelial - cell antibodies
11. NEI interactions: the role of cortistatin/ somatostatin
12. Prolactin And Growth Hormone Responses To Hypoglycemia In Patients With Systemic Sclerosis And Psoriatic Arthritis

Part III: The Peripheral Nervous System: Nerve Fibres, Neuropeptides and Clinical Links in Arthritis
13. Innervation of the joint and role of Neuropeptides
14. Neurogenic Inflammation and Arthritis
15. Role of the Sympathetic Nervous System in Chronic Arthritis
16. Vagus nerve signaling and fever / inflammation
17. Adrenergic Modulation of the innate Immunity
18. Sleep and fatigue in Rheumatic Diseases: George Chrousos
19. Alexithymia And Neuroendocrine-Immune Response In Patients With Autoimmune Disease
20. The Sympathetic Nervous System Influences Cd4+Cd25+ Splenocytes To Aggravate Collagen-Induced Arthritis In The Adoptive Cell Transfer Model In Dba/1 Mice

Part IV: The Role of Gonadal Hormones: Sex Hormones and Rheumatic Diseases
21. Epidemiological aspects of Rheumatic Diseases: The Sex Ratio
22. Developmental and environmental factors and Sex Hormones
23. Inflammation and Sex Hormone Metabolism
24. Estrogens in pregnancy and Systemic Lupus Erythematosus
25. DHEA in Systemic Lupus Erythematosus and Sjogren Syndrome
26. Androgen And Prolactin (Prl) Levels In Systemic Sclerosis (SSc): Relationship With Disease Severity
27. Role Of Estrogens In Inflammatory Response: Expression Of Estrogen Receptors In Peritoneal Fluid Macrophages From Endometriosis
28. Estrogen Metabolites And Rheumatoid Arthritis: Effects On Proliferation Of Activated Human Monocytes
29. Hormonal Alterations In Type I And II Hereditary Angioedema And Role Of Danazol In Steroid Hormone Conversion
30. BMD, Testosterone Plasma Levels And Lifestyles Correlations In Argentine Men Population

Part V: Glucocorticoids as Endogenous Neuroendocrine Immune Modulators: New Perspectives in the Therapy of Rheumatic Diseases
31. Mechanisms of Glucocorticoid action and New Glucocorticoids
32. Are glucocorticoids Disease Modifying Antirheumatic Drugs (DMARDS)?
33. Less side effects than expected from Glucocorticoids: How to manage?
34. Circadian rhythms: Glucocorticoids and Arthritis
35. Oral pulsed dexamethasone therapy in early rheumatoid arthritis: a pilot study
36. Glucocorticoid treatment induces different hormonal and cytokine responsiveness in polymyalgia rheumatica and rheumatoid arthritis with polymyalgia-like onset compared with elderly-onset rheumatoid arthritis
37. Is The Course Of Steroid-Treated Polymyalgia Rheumatica More Benign In Men Than In Women?

Part VI: Clinical Aspects: The Neuroendocrine and the Immune Systems in Rheumatology
38. Neuroendocrine predictors of autoimmunity
39. Auto antibodies and pregnancy in Rheumatic Diseases
40. Cytokines and pregnancy in Rheumatic Diseases
41. Immune interactions in Systemic Lupus Erythematosus
42. Defective placentation in antiphospholipid associated fetal loss: more
hormone abnormalities then clotting?
43. Endocrine regulation of Suppressor Lymphocytes: role of the Glucocorticoid-Induced TNF- like receptor
44. Multi-Endocrine Dysregulation In Fibromyalgic Patients
45. Neuroendocrine Manifestations Of Phospholipid Antibody Disease
Part VII: Clinical Evidences: Anti-TNF strategies and effects on Neuroendocrine Immune Mechanisms in Rheumatic Diseases
46. Anti-TNF and HPA axis
47. Anti-TNF and Sex Hormones
48. The effects of TNF-blocking therapies on joint damage:
49. TNF-alpha stimulates DHEA metabolism in human fibroblast-like synoviocytes: a role for NFkB and AP-1 in the regulation of Cyp7p expression
50. Atherosclerosis And Rheumatoid Arthritis: Effects Of Anti-Tnf Alpha Therapy On Lipid Profile
51. Bone Metabolism Variations During Anti-Tnf Alpha Therapy In Active Rheumatoid Arthritis Patients
52. The Selective Blockade Of TNFa reveals a TNFa/Chromogranin: A Pathway In Patients With Rheumatoid Arthritis:
53. Nerve Growth Factor And Brain Derived Growth Factor Levels In Patients With Rheumatoid Arthritis Treated With TNFa Blockers

Part VIII: Clinical Perspectives: Lipid Metabolism in Rheumatic Diseases
54. Control of inflammation by Adipocytes
55. Leptin is a link between adipose tissue and inflammation
56. Anti-TNF therapy and Arteriosclerosis - The need to test the inflammation hypothesis in clinical Trials
57. Adiponectin and Rheumatoid Arthritis
Part IX: Miscellaneous
58. Cell Stress-Response In Skeletal Muscle Myofibers
59. Stress-Protein Expression In Skeletal Muscle Cells Of Patients Affected With Autoimmune Myositis
60. Chromograin-A as a Novel Marker Of Systemic Involvement In Rheumatoid Arthritis


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