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Kelley's Textbook of Rheumatology, 9th Edition





381.60€ 307.19€
Discount -20 %
ISBN - 9781437717389
Autor(es) - Gary S. Firestein, Ralph C. Budd, Sherine E Gabriel, Iain B. McInnes, James R O Dell
Editora - Saunders
Ano de Edição - 2013
N º de Páginas - 1984


2-Volume Set


Description


Staying current in a field that's advancing rapidly is difficult. Now more than ever, Kelley's Textbook of Rheumatology, 8th Edition helps you better understand today's scientific underpinnings of rheumatic diseases, so that you can better manage your patients. With its new full-color design, scholarly approach to scientific concepts, and sweeping updates, you'll have a source of knowledge at your disposal to help you face even your toughest challenges. And this Expert Consult Premium Edition, includes a companion web site that lets you access this regularly updated, unparalleled guidance where and when you need it most.

KEY FEATURES


- Includes the entire contents of the book online—fully searchable—as well as access to regular updates • an image library for use in electronic presentations • streaming videos that demonstrate the complete musculoskeletal exam, including abnormal findings and the arthroscopic presentation of diseased joints • links to PubMed • self-assessment questions • and more.
- Features state-of-the-art, evidence-based guidance to help you offer your patients the best possible outcomes.
- Provides an increased understanding of mechanisms and molecules involved in the pathogenesis of disease.

NEW TO THIS EDITION

- Includes detailed coverage of the very latest breakthroughs and the newest clinical algorithms to help you gain a thorough understanding of the whys as well as the hows of rheumatic disease management.
- Features new expert authors and new chapters that help you identify key effector mechanisms in autoimmune diseases and inflammation and apply the newest therapeutic modalities.
- Offers expanded coverage of imaging modalities so you can diagnose, monitor, and manage rheumatic disease more effectively.
Incorporates a new full-color design—complete with more than 900 full-color illustrations—for quick access to the answers you need.


Table of Contents

VOLUME I

STRUCTURE AND FUNCTION OF BONE, JOINTS, AND CONNECTIVE TISSUE, 1
1 Biology of the Normal Joint, 1
2 Synovium, 20
3 Cartilage and Chondrocytes, 33
4 Biology, Physiology, and Morphology of Bone, 61
5 Muscle: Anatomy, Physiology, and Biochemistry, 67
6 Biomechanics, 79
7 Regenerative Medicine and Tissue Engineering, 90
8 Proteinases and Matrix Degradation, 97

CELLS INVOLVED IN AUTOIMMUNE DISEASES AND INFLAMMATION, 117
9 Dendritic Cells, 117
10 Mononuclear Phagocytes in Rheumatic Diseases, 134
11 Neutrophils, 152
12 Eosinophils, 170
13 T Lymphocytes, 174
14 B Cells, 191
15 Fibroblasts and Fibroblast-like Synoviocytes, 215
16 Mast Cells, 232
17 Platelets, 245

EFFECTOR MECHANISMS IN AUTOIMMUNITY AND
INFLAMMATION, 255
18 Innate Immunity, 255
19 Adaptive Immunity and Organization of Lymphoid
Tissues, 268
20 Autoimmunity, 281
21 Genetics of Rheumatic Diseases, 299
22 Epigenetics, 316
23 Complement System, 325
24 Prostaglandins, Leukotrienes, and Related Compounds, 340
25 Cell Recruitment and Angiogenesis, 358
26 Cytokines, 369
27 Cell Survival and Death in Rheumatic Diseases , 382
28 Experimental Models for Rheumatoid
Arthritis, 400
29 Neural Regulation of Pain and Infl ammation, 413

BROAD ISSUES IN THE APPROACH TO RHEUMATIC DISEASE, 431
30 Principles of Epidemiology in Rheumatic Disease, 431
31 Economic Burden of Rheumatic
Diseases, 440
32 Clinical Trial Design and Analysis, 452
33 Assessment of Health Outcomes, 462
34 Biologic Markers, 476
35 Occupational and Recreational Musculoskeletal Disorders, 493
36 Cardiovascular Risk in Rheumatic Disease, 505
37 Cancer Risk in Rheumatic Diseases, 515
38 Introduction to Physical Medicine, Physical Therapy, and Rehabilitation, 528
39 Pregnancy in the Rheumatic Diseases, 540

EVALUATION OF GENERALIZED AND LOCALIZED SYMPTOMS, 559
40 History and Physical Examination of the Musculoskeletal System, 559
41 Acute Monoarthritis, 577
42 Polyarticular Arthritis, 587
43 The Skin and Rheumatic Diseases, 599
44 The Eye and Rheumatic Diseases, 617

DIFFERENTIAL DIAGNOSIS OF REGIONAL
AND DIFFUSE MUSCULOSKELETAL
PAIN, 625
45 Neck Pain, 625
46 Shoulder Pain, 639
47 Low Back Pain, 665
48 Hip and Knee Pain, 683
49 Foot and Ankle Pain, 700
50 Hand and Wrist Pain, 708
51 Temporomandibular Joint Pain, 721
52 Fibromyalgia, 733

DIAGNOSTIC TESTS AND PROCEDURES IN RHEUMATIC DISEASES, 753
53 Synovial Fluid Analyses, Synovial Biopsy, and Synovial Pathology , 753
54 Arthrocentesis and Injection of Joints and Soft Tissue, 770
55 Antinuclear Antibodies, 789
56 Autoantibodies in Rheumatoid Arthritis, 804
57 Acute Phase Reactants and the Concept of Inflammation, 818
58 Imaging Modalities in Rheumatic Diseases , 830

PHARMACOLOGY OF ANTIRHEUMATIC DRUGS, 871
59 Prostanoid Biology and Its Therapeutic Targeting, 871
60 Glucocorticoid Therapy, 894
61 Traditional DMARDs: Methotrexate, Lefl unomide, Sulfasalazine, Hydroxychloroquine, and Combination Therapies, 917
62 Immunosuppressive Drugs, 941
63 Anticytokine Therapies, 957
64 Cell-Targeted Biologics and Targets: Rituximab, Abatacept, and Other Biologics, 978
65 Antihyperuricemic Agents, 1001
66 Analgesic Agents in Rheumatic Disease, 1014
67 Psychosocial Management of Rheumatic Diseases, 1034
68 Nutrition and Rheumatic Diseases, 1044

VOLUME II

RHEUMATOID ARTHRITIS, 1059
69 Etiology and Pathogenesis of Rheumatoid Arthritis , 1059
70 Clinical Features of Rheumatoid Arthritis , 1109
71 Treatment of Rheumatoid Arthritis, 1137
72 Early Synovitis and Early Undifferentiated Arthritis, 1161
73 Sjögren's Syndrome, 1169

SPONDYLOARTHROPATHIES, 1193
74 Pathogenesis of Ankylosing Spondylitis and Reactive Arthritis, 1193
75 Ankylosing Spondylitis, 1202
76 Reactive Arthritis and Undifferentiated Spondyloarthritis, 1221
77 Psoriatic Arthritis, 1232
78 Enteropathic Arthritis, 1251

SYSTEMIC LUPUS ERYTHEMATOSUS AND RELATED SYNDROMES, 1269
79 Etiology and Pathogenesis of Systemic Lupus Erythematosus, 1269
80 Clinical Features of Systemic Lupus Erythematosus, 1283
81 Treatment of Systemic Lupus Erythematosus, 1304
82 Antiphospholipid Syndrome, 1331

SCLERODERMA, INFLAMMATORY MYOPATHIES, AND OVERLAP SYNDROMES, 1343
83 Etiology and Pathogenesis of Scleroderma, 1343
84 Clinical Features and Treatment of Scleroderma, 1366
85 Infl ammatory Diseases of Muscle and Other Myopathies, 1404
86 Overlap Syndromes, 1431

VASCULITIS, 1453
87 Classifi cation and Epidemiology of Systemic Vasculitis, 1453
88 Giant Cell Arteritis, Polymyalgia Rheumatica, and
Takayasu's Arteritis, 1461
89 Antineutrophil Cytoplasm Antibody-Associated
Vasculitis, 1481
90 Polyarteritis Nodosa and Related Disorders, 1498
91 Immune Complex-Mediated Small Vessel Vasculitis, 1508
92 Primary Angiitis of the Central Nervous System, 1518
93 Behçet's Disease, 1525

CRYSTAL-INDUCED AND INFLAMMASOME-MEDIATED
INFLAMMATION, 1533
94 Etiology and Pathogenesis of Hyperuricemia
and Gout , 1533
95 Clinical Features and Treatment of Gout, 1554
96 Calcium Crystal Disease: Calcium Pyrophosphate Dihydrate and Basic Calcium Phosphate , 1576
97 Familial Autoinfl ammatory Syndromes, 1597

CARTILAGE, BONE, AND HERITABLE CONNECTIVE TISSUE DISORDERS, 1617
98 Pathogenesis of Osteoarthritis, 1617
99 Clinical Features of Osteoarthritis, 1636
100 Treatment of Osteoarthritis , 1646
101 Metabolic Bone Disease, 1660
102 Proliferative Bone Diseases, 1680
103 Osteonecrosis, 1692
104 Relapsing Polychondritis , 1712
105 Heritable Diseases of Connective Tissue, 1719

RHEUMATIC DISEASES OF CHILDHOOD, 1741
106 Etiology and Pathogenesis of Juvenile Idiopathic Arthritis, 1741
107 Treatment of Juvenile Idiopathic Arthritis, 1752
108 Pediatric Systemic Lupus Erythematosus,
Dermatomyositis, Scleroderma, and Vasculitis, 1771

INFECTION AND ARTHRITIS, 1801
109 Bacterial Arthritis, 1801
110 Lyme Disease, 1815
111 Mycobacterial Infections of Bones and Joints, 1829
112 Fungal Infections of Bones and Joints, 1841
113 Rheumatic Manifestations of Human Immunodeficiency Virus Infection, 1851
114 Viral Arthritis, 1865
115 Poststreptococcal Arthritis and Rheumatic Fever, 1875

ARTHRITIS ACCOMPANYING SYSTEMIC DISEASE, 1889
116 Amyloidosis, 1889
117 Sarcoidosis , 1898
118 Hemochromatosis, 1907
119 Hemophilic Arthropathy, 1915
120 Rheumatologic Manifestations of Hemoglobinopathies, 1924
121 Endocrine Diseases and the Musculoskeletal System, 1927
122 Musculoskeletal Syndromes in Malignancy, 1934
123 Tumors and Tumor-like Lesions of Joints and Related Structures, 1951

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