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Dubois' Lupus Erythematosus and Related Syndromes, 8th Edition

179.14€ 161.23€
Desconto -10 %
ISBN - 9781437718935
Autor(es) - Daniel Wallace, Bevra Hannahs Hahn
Editora - Saunders
Ano de Edição - 2013
N º de Páginas - 712


Recognized for more than 45 years as the definitive text in the field, Dubois’ Lupus Erythematosus and Related Syndromes strikes the perfect balance between basic science and clinical expertise, providing the evidence-based findings, treatment consensuses, and practical clinical information you need to confidently diagnose and manage SLE.

Key Features

- Broaden your understanding with comprehensive coverage of every aspect of cutaneous and systemic lupus erythematosus, including definitions, pathogenesis, autoantibodies, clinical and laboratory features, management, prognosis, and patient education.
- Experience clinical scenarios with vivid clarity through a heavily illustrated, full-color format which includes fundamental images of lupus rashes as well as graphs, algorithms, and differential diagnosis comparisons.
New to This Edition

- Discover the latest in systemic lupus erythematosus with new chapters on important emerging topics such as socioeconomic and disability aspects; and rigorously updated chapters that include expanded coverage of the nervous system, and the most in-depth discussion of immunity and regulatory cells.
- Learn from the very best. World-renowned rheumatologists Drs. Daniel Wallace and Bevra Hannahs Hahn, along with new associate editors Drs. Michael Weisman, Ronald Van Vollenhoven, Nan Shen, and David Isenberg, present definitive coverage on new and rapidly changing areas in the field.
- Rely on it anytime, anywhere! Access the full text, image bank, and bonus online-only chapters at

Table of Contents

Section I: What is Lupus?
1. Definition and classification of Lupus and Lupus-Related Disorders
2. The Epidemiology of Lupus

Section II: The Pathogenesis of Lupus
3. The Pathogenesis of SLE
4. Genetics of Human SLE
5. Epigenetics of Lupus
6. The Innate Immune System in SLE
7. Cytokines and Interferons in Lupus
8. The Structure and Derivation of Antibodies and Autoantibodies
9. T Cells
10. Regulatory Cells in SLE
11. Apoptosis, Necrosis, and Autophagy
12. Abnormalities in Immune Complex Clearance and Fcy Receptor Function
13. Neural-Immune Interactions: Principles and Relevance to SLE
14. Complement and SLE
15. Mechanisms of Acute Inflammation and Vascular Injury in SLE
16. Mechanisms of Tissue Damage - Free Radicals and Fibrosis
17. Animal Models of SLE
18. Pathogenic Mechanisms in Lupus Nephritis

Section III: Autoantibodies
19. Immune Tolerance Defects in Lupus
20. Autoantibodies
21. Autoantigenesis and Entigen-Based Therapy and Vaccination in SLE

Section IV: Clinical Aspects of SLE
22. Overview and Clinical Presentation
23. Pathomechanisms of Cutaneous Lupus Erythematosus
24. Skin Disease in Cutaneous Lupus Erythematosus
25. The Musculoskeletal System and Bone Metabolism
26. Pathogenesis and Treatment of Atherosclerosis in Lupus
27. Cardiopulmonary Disease in SLE
28. Pathogenesis of the Nervous System
29. Clinical Aspects of the Nervous System
30. Psychopathology, Neurodiagnostic Testing, and Imaging
31. Ocular, Aural, and Oral Manifestations
32. Management of Sjögren Syndrome in Patients with SLE
33. Gastrointestinal and Hepatic Manifestations
34. Hematologic and Lymphoid Abnormalities in SLE
35. Clinical and Epidemiologic Features of Lupus Nephritis
Section V: The Reproductive System & Hormones
36. Pregnancy in Women with SLE
37. Neonatal Lupus Erythematosus
38. Reproductive and Hormonal Issues in Women with Autoimmune Diseases

Section VI: Special Considerations, Subsets of SLE and Lupus-Related Syndromes
39. Drug-Induced Lupus: Etiology, Pathogenesis, and Clinical Aspects
40. SLE in Childhood and Adolescence
41. Mixed Connective Tissue Disease and Undifferentiated Connective Tissue Disease
42. Clinical Aspects of the Antiphospholipid Syndrome

Section VII: Assessment of Lupus
43. Clinical Application of Serologic Tests, Serum Protein Abnormalities, and Other Clinical Laboratory Tests in SLE
44. Differential Diagnosis and Disease Associations
45. SLE and Infections
46. Clinical Measures, Metrics and Indices

Section VIII: Management of SLE
47. Principles of Therapy, Local Measures, Nonsteroidal Medications
48. Systemic Glucocorticoid Therapy in SLE
49. Antimalarial Medications
50. Immunosuppressive Drug Therapy
51. Specialized Treatment Approaches and Niche Therapies for Lupus Subsets
52. Adjunctive and Preventive Measures
53. Novel Therapies for SLE: Biological Agents Available in Practice Today
54. Critical Issues in Drug Development for SLE
55. Socioeconomic and Disability Aspects

Section IX: Outcomes and Future Considerations
56. Investigational Agents and Future Therapy for SLE
57. Mortality in SLE

Appendix: Lupus Resource Materials

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