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The Cell: A Molecular Approach, 6th Edition





86.39€ 77.75€
Desconto -10 %
ISBN - 9780878939640
Autor(es) - Geoffrey M. Cooper, Robert E. Hausman
Editora - Sinauer Associates
Ano de Edição - 2013
N º de Páginas - 760


Description

Published in February 2013,The Cell presents current comprehensive science in a readable and cohesive text that students can master in the course of one semester. This new edition retains the overall organization, themes, and special features of the Fifth Edition, including Key Experiment and Molecular Medicine essays, chapter sidebars that highlight areas of interest and clinical applications, and end-of-chapter questions with answers at the back of the book. Yet, the Sixth Edition has been updated throughout to reflect major advances since publication of the Fifth Edition in 2009. [See the annotated contents section for details.] In addition, many of the figures have been revised to achieve a contemporary graphic look.


Table of Contents

Preface
Organization and Features of The Cell
Media and Supplements to Accompany The Cell

PART I. INTRODUCTION
1. An Overview of Cells and Cell Research
•Updated discussion of the evolution of multicellular organisms
•Genomes of Paramecium, Chlamydomonas, and Volvox

2. The Composition of Cells
•Updated discussion of proteomics
•Protein content of subcellular organelles

3. Cell Metabolism
•Importance of glycolysis in cancer cell metabolism

4. Fundamentals of Molecular Biology
•Next-generation sequencing
•Updated information on mouse gene knockouts

PART II. THE FLOW OF GENETIC INFORMATION
5. The Organization and Sequences of Cellular Genomes
•New chapter organization
•Role of retrotransposons in determining the length of dog legs
•Updated discussion of genome sequences
•Global analyses of gene expression
•Sequencing individual human genomes

6. Replication, Maintenance, and Rearrangements of Genomic DNA
•New chapter organization
•Streamlined discussion of recombination and repair of double-strand breaks
•Updated information on the role of transposons

7. RNA Synthesis and Processing
•Role of cohesin in gene regulation
•Genome-wide analysis of transcription factor binding
•Role of Myc in control of transcriptional elongation
•Updated discussion of histone modifications at promoters and enhancers
•Transcriptional regulation by long noncoding RNAs

8. Protein Synthesis, Processing, and Regulation
•Updated discussion of internal ribosome entry sites
•Protein folding and human disease: cystic fibrosis, Alzheimer’s, and Parkinson’s
•Revised discussion of protein regulation by acetylation, glycosylation, and sumoylation


PART III. CELL STRUCTURE AND FUNCTION
9. The Nucleus
•Connection of the nuclear lamina to the cytoskeleton
•Updated discussion of mRNA export from the nucleus
•Updated information on nuclear bodies
•Functions of the nucleolus beyond ribosome production

10. Protein Sorting and Transport
•Updated discussion of endoplasmic reticulum-associated degradation (ERAD)
•New material on the unfolded protein response
•Streamlined treatment of formation of coated vesicles

11. Bioenergetics and Metabolism
•Mitochondrial fission and fusion
•Reorganized and updated discussion of mitochondrial import
•New material on peroxisome assembly

12. The Cytoskeleton and Cell Movement
•Chapter reorganized and streamlined
•Updated discussion of dynamic instability of actin filaments and microtubules
•Expanded information on microtubule-associated proteins

13. The Plasma Membrane
•Updated discussion of lipid rafts
•Structure of mitochondrial voltage-gated anion channel
•Streamlined discussion of coated vesicle formation

14. Cell Walls, the Extracellular Matrix, and Cell Interactions
•Revised treatment of plant cell walls
•Updated discussion of laminins
•Streamlined discussion of the regulation of integrins

PART IV. CELL REGULATION
15. Cell Signaling
•New information on plant hormones
•Regulation of autophagy by mTOR signaling
•Updated discussion of signaling from cell adhesion molecules
•Crosstalk between the PI 3-kinase and ERK Pathways

16. The Cell Cycle
•Expanded discussion of Aurora and Polo-like kinases
•Updates on APC/C and the spindle assembly checkpoint
•Potential role of noncoding RNAs in homologous chromosome pairing during meiosis

17. Cell Death and Cell Renewal
•New chapter section: Pluripotent Stem Cells, Cellular Reprogramming, and Regenerative Medicine
•Updated discussion of induced pluripotent stem cells
•The transcriptional program of embryonic stem cells
•Transdifferentiation of somatic cells

18. Cancer
•Streamlined discussion of tumor viruses
•Merkel cell polyomavirus and human cancer
•Genome-wide analysis of mutations in human cancers
•Progress in development of oncogene-targeted drugs
Answers to Questions

Glossary
Illustration Credits
Index

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