This comprehensive and authoritative book discusses the critical role of the utero-placenta in neurodisability, both at term and preterm. It examines aspects of fetal compromise and possible cerebro-protective interventions, recent evidence on fetal growth and mental illness, as well as cerebro-therapeutics. Throughout the book, information from the basic sciences placed within the clinical context.
•Written by leading obstetricians, neonatologists, paediatricians and pathologists. •Discusses the role of placenta in the pathophysiology of CNS •Examines recent evidence of endocrine, haematological and inflammatory origins of utero-placental dysfunction •Reviews latest advances in antepartum and perinatal imaging
Table of Contents
1. Placental pathology and perinatal brain injury 2. Abnormal Placental Phenotypes 3. Aberrant placental endocrinology, fetal growth and neurodevelopment 4. The rheology of utero-placental and feto-placental blood flow 5. Inflammation and Placentation 6. Infections and the fetal inflammatory response 7. Cerebral ischaemia and white matter injury 8. In utero imaging of the human placenta 9. Cerebral Function and Fetal Growth Restriction 10. Placental programming and mental illness: fetal growth and schizophrenia 11. Cerebro-therapeutics 12. Summing up and unsolved problems