A condensed, easier-to-understand student version of the acclaimed Tietz Textbook of Clinical Chemistry and Molecular Diagnostics, Tietz Fundamentals of Clinical Chemistry and Molecular Diagnostics, 7th Edition uses a laboratory perspective in providing the clinical chemistry fundamentals you need to work in a real-world, clinical lab. Coverage ranges from laboratory principles to analytical techniques and instrumentation, analytes, pathophysiology, and more. New content keeps you current with the latest developments in molecular diagnostics. From highly respected clinical chemistry experts Carl Burtis and David Bruns, this textbook shows how to select and perform diagnostic lab tests, and accurately evaluate results.
•Authoritative, respected author team consists of two well-known experts in the clinical chemistry world. •Coverage of analytical techniques and instrumentation includes optical techniques, electrochemistry, electrophoresis, chromatography, mass spectrometry, enzymology, immunochemical techniques, microchips, automation, and point of care testing. •Learning objectives begin each chapter, providing measurable outcomes to achieve after completing the material. •Key words are listed and defined at the beginning of each chapter, and bolded in the text. •A glossary at the end of the book makes it quick and easy to look up definitions of key terms. •More than 500 illustrations plus easy-to-read tables help you understand and remember key concepts.
New to this Edition
•New chapters on molecular diagnostics include the principles of molecular biology, nucleic acid techniques and applications, and genomes and nucleic acid alterations, reflecting the changes in this rapidly evolving field. •New content on clinical evaluation of methods, kidney function tests, and diabetes is added to this edition. •NEW multiple-choice review questions at the end of each chapter allow you to measure your comprehension of the material. •NEW case studies on the Evolve companion website use real-life scenarios to reinforce concepts.
I. PRINCIPLES OF LABORATORY MEDICINE 1. Clinical Chemistry, Molecular Diagnostics, and Laboratory Medicine 2. Selection and Analytical Evaluation of Methods — With Statistical Techniques 3. Clinical Evaluation of Methods 4. Evidence-Based Laboratory Medicine 5. Establishment and Use of Reference Values 6. Specimen Collection, Processing, and Other Preanalytical Variables 7. Quality Management
II. ANALYTICAL TECHNIQUES AND INSTRUMENTATION 8. Principles of Basic Techniques and Laboratory Safety 9. Optical Techniques 10. Electrochemistry and Chemical Sensors 11. Electrophoresis 12. Chromatography 13. Mass Spectrometry 14. Enzyme and Rate Analyses 15. Immunochemical Techniques 16 Automation 17. Point-of-Care Instrumentation
III. ANALYTES 18. Amino Acids, Peptides, and Proteins 19. Serum Enzymes 20. Tumor Markers and Cancer Genes 21. Kidney Function Tests — Creatinine, GFR, Urea, and Uric Acid 22. Carbohydrates 23. Lipids, Lipoproteins, Apolipoproteins, and Other Cardiac Risk Factors 24. Electrolytes and Blood Gases 25. Hormones 26. Catecholamines and Serotonin 27. Vitamins, Trace Elements, Nutritional Assessment 28. Hemoglobin, Iron, and Bilirubin 29. Porphyrins and Porphyrias 30. Therapeutic Drugs and Their Management 31. Clinical Toxicology 32. Toxic Metals
IV. PATHOPHYSIOLOGY 33. Diabetes 34. Cardiovascular Disease 35. Kidney Disease 36. Physiology and Disorders of Water, Electrolyte, and Acid-Base Metabolism 37. Liver Disease 38. Gastrointestinal and Pancreatic Diseases 39. Disorders of Bone and Mineral Metabolism 40. Disorders of the Pituitary Gland 41. Disorders of the Adrenal Cortex 42. Thyroid Disorders 43. Reproduction-Related Disorders 44. Pregnancy and Prenatal Testing 45. Newborn Screening and Inborn Errors of Metabolism 46. Pharmacogenetics
V. MOLECULAR DIAGNOSTICS NEW! 47. Principles of Molecular Biology 48. Nucleic Acid Techniques and Applications 49. Genomes and Nucleic Acid Alterations
VI. REFERENCE INFORMATION 50. Reference Information for the Clinical Laboratory