Practical guidance on differential diagnosis based on pathology and clinical presentation
Peripheral nerve analysis is a challenging task for pathologists, given the advent of new diagnoses and techniques of analysis and the impact of molecular genetics. This book presents a simple, logical method for constructing a differential diagnosis based on pathology and clinical presentation. It also provides advice on the selection of ancillary molecular, immunohistochemical and genetic techniques to establish a definitive diagnosis. Clear, authoritative guidance is offered on diagnosis of the full range of neuropathies with the aid of a wealth of high-quality color photomicrographs and electron micrographs. The pathologist will benefit greatly from the identification of a variety of artifacts and normal structures occasionally encountered in nerve biopsies that need to be distinguished from specific pathologic alterations. This user-friendly, practical text will be an invaluable aid in achieving the most specific diagnosis possible.
Table of Contents
- Peripheral Neuropathy and the Role of Nerve Biopsy - Normal Anatomy of the Peripheral (Sural) Nerve - Quantitative Techniques - The Axon: Normal Structure and Pathological Alterations - Schwann Cells and Myelin in the Peripheral Nervous System - The Peripheral Nerve Vasculature - Examination of the Peripheral Nerve Biopsy - Clinical Aspects of Peripheral Neuropathy - The Inflammatory Demyelinating Neuropathies - Idiopathic Inflammatory Neuropathies - Infectious Diseases Causing Neuropathy - Leprous Neuropathy - Vasculitic Neuropathy - Dysproteinemic Neuropathies - Amyloid Neuropathy - Neuropathy Associated with Neoplasia - Neuropathy Associated with Endocrine and Metabolic Disease - Toxic Neuropathies - Genetically Determined Neuropathies - Storage Diseases - Unclassified Neuropathies and Mimics