Handle the toughest clinical challenges with Comprehensive Clinical Nephrology. The world’s leading authorities in the field, Drs. Richard J. Johnson, John Feehally, Jürgen Floege and a team of international experts have meticulously updated this fifth edition to continue to provide the level of expert information that readers rely on from this classic reference.
- The right amount of basic science and practical clinical guidance assists in making efficient and informed decisions. - Extensive updates on key topics keep you at the forefront of the field.
New to This Edition
- New chapters on glomerulonephritis associated with complement disorders, interventional treatments for hypertension, renal disease and cancer, and epidemiology and prognostic impact of acute kidney injury. - Over 1,500 color illustrations highlight key topics and detail pathogenesis for a full range of kidney conditions and clinical management. - Hundreds of color coded algorithms promote quick reference and to help you retain concepts. - Over 400 NEW self-assessment questions and fully searchable text available online at ExpertConsult.
Section II: Investigation of Renal Disease 3. Assessment of Renal Function 4. Urinalysis 5. Imaging 6. Renal Biopsy
Section III: Fluid and Electrolyte Disorders 7. Disorders of Extracellular Volume 8. Disorders of Water Metabolism 9. Disorders of Potassium Metabolism 10. Disorders of Calcium, Phosphate, and Magnesium Metabolism 11. Normal Acid-Base Balance 12. Metabolic Acidosis 13. Metabolic Alkalosis 14. Respiratory Acidosis, Respiratory Alkalosis, and Mixed Disorders
Section IV: Glomerular Disease 15. Introduction to Glomerular Disease: Clinical Presentations 16. Introduction to Glomerular Disease: Histologic Classification and Pathogenesis 17. Minimal Change Nephrotic Syndrome 18. Primary and Secondary (Non-Genetic) Causes of Focal and Segmental Glomerulosclerosis 19. Inherited Causes of Nephrotic Syndrome 20. Membranous Nephropathy 21. Membranoproliferative Glomerulonephritis and Cryoglobulinemic Glomerulonephritis 22. Glomerulonephritis Associated with Complement Disorders 23. IgA Nephropathy and Henoch-Schonlein Nephritis 24. Antiglomerular Basement Membrane Disease and Goodpasture Disease 25. Renal and Systemic Vasculitis 26. Lupus Nephritis 27. Renal Amyloidosis and Glomerular Disease with Monoclonal Immunoglobulin Deposition 28. Other Glomerular Disorders and Antiphospholipid Syndrome 29. Thrombotic Microangiopathies, Including Hemolytic Uremic Syndrome
Section V: Diabetic Nephropathy 30. Pathogenesis, Clinical Manifestations, and Natural History of Diabetic Nephropathy 31. Prevention and Treatment of Diabetic Nephropathy 32. Management of the Diabetic Patient with Chronic Kidney Disease
Section VI: Hypertension 33. Normal Blood Pressure Control and the Evaluation of Hypertension 34. Primary Hypertension 35. Nonpharmacologic Prevention and Treatment of Hypertension 36. Pharmacologic Treatment of Hypertension 37. Evaluation and Treatment of Hypertensive Urgencies and Emergencies 38. Interventional Treatments for Resistant Hypertension 39. Renovascular Hypertension and Ischemic Renal Disease 40. Endocrine Causes of Hypertension - Aldosterone 41. Endocrine Causes of Hypertension 42. Neurogenic Hypertension, Including Hypertension Associated with Stroke or Spinal Cord Injury
Section VII: Pregnancy and Renal Disease 43. Renal Physiology in Normal Pregnancy 44. Renal Complications in Normal Pregnancy 45. Pregnancy with Preexisting Kidney Disease
Section VIII: Hereditary and Congenital Diseases of the Kidney 46. Autosomal Dominant Polycystic Kidney Disease 47. Other Cystic Kidney Diseases 48. Alport and Other Familial Glomerular Syndromes 49. Inherited Disorders of Sodium and Water Handling 50. Fanconi Syndrome and Other Proximal Tubule Disorders 51. Sickle Cell Disease 52. Congenital Anomalies of the Kidney and Urinary Tract
Section IX: Infectious Diseases and the Kidney 53. Bacterial Urinary Tract Infections 54. Tuberculosis of the Urinary Tract 55. Fungal Infections of the Urinary Tract 56. The Kidney in Schistosomiasis 57. Glomerular Diseases Associated with Infection 58. Human Immunodeficiency Virus Infection and the Kidney
Section X: Urologic Disorders 59. Nephrolithiasis and Nephrocalcinosis 60. Urinary Tract Obstruction 61. Urologic Issues for the Nephrologist
Section XI: Tubulointerstitial and Vascular Diseases 62. Acute Interstitial Nephritis 63. Primary Vesicoureteral Reflux and Reflux Nephropathy 64. Chronic Interstitial Nephritis 65. Myeloma and the Kidney 66. Thromboembolic Renovascular Disease
Section XIII: Renal Disease and Cancer 68. Onco-Nephrology: Renal Disease in Cancer Patients
Section XIV: Acute Kidney Injury 69. Pathophysiology and Etiology of Acute Kidney Injury 70. Acute Kidney Injury in the Tropics 71. Diagnosis and Clinical Evaluation of Acute Kidney Injury 72. Epidemiology and Prognostic Impact of Acute Kidney Injury 73. Prevention and Nondialytic Management of Acute Kidney Injury 74. Dialytic Management of Acute Kidney Injury and Intensive Care Unit Nephrology 75. Management of Refractory Heart Failure 76. Hepatorenal Syndrome
Section XV: Drug Therapy in Kidney Disease 77. Principles of Drug Therapy, Dosing, and Prescribing in Chronic Kidney Disease and Renal Replacement Therapy 78. Herbal and Over-the-Counter Medicines and the Kidney
Section XVI: Chronic Kidney Disease and the Uremic Syndrome 79. Epidemiology, Natural History, and Pathophysiology of Chronic Kidney Disease 80. Retarding Progression of Kidney Disease 81. Clinical Evaluation and Management of Chronic Kidney Disease 82. Cardiovascular Disease in Chronic Kidney Disease 83. Anemia in Chronic Kidney Disease 84. Other Blood and Immune Disorders in Chronic Kidney Disease 85. Bone and Mineral Metabolism in Chronic Kidney Disease 86. Neurologic Complications in Chronic Kidney Disease 87. Gastroenterology and Nutrition in Chronic Kidney Disease 88. Dermatologic Manifestations of Chronic Kidney Disease 89. Acquired Cystic Kidney Disease and Malignant Neoplasms
Section XVII: Dialytic Therapies 90. Approach to Renal Replacement Therapy 91. Vascular Access for Dialytic Therapies 92. Diagnostic and Interventional Nephrology 93. Hemodialysis: Principles and Techniques 94. Hemodialysis: Outcomes and Adequacy 95. Acute Complications During Hemodialysis 96. Peritoneal Dialysis: Principles, Techniques, and Adequacy 97. Complications of Peritoneal Dialysis 98. Dialytic Therapies for Drug Overdose and Poisoning 99. Plasma Exchange
Section XVIII: Transplantation 100. Immunologic Principles in Kidney Transplantation 101. Immunosuppressive Medications in Kidney Transplantation 102. Evaluation and Preoperative Management of Kidney Transplant Recipient and Donor 103. Kidney Transplantation Surgery 104. Prophylaxis and Treatment of Kidney Transplant Rejection 105. Medical Management of the Kidney Transplant Recipient: Infections, Malignant Neoplasms, and Gastrointestinal Disorders 106. Medical Management of the Kidney Transplant Recipient: Cardiovascular Disease and Other Issues 107. Chronic Allograft Injury 108. Recurrent Disease in Kidney Transplantation 109. Outcomes of Renal Transplantation 110. Pancreas and Islet Transplantation 111. Kidney Disease in Liver, Cardiac, Lung, and Hematopoietic Cell Transplantation