Drs. Busuttil and Klintmalm present Transplantation of the Liver, 3rd Edition, which has been thoroughly revised to offer you the latest protocols, surgical approaches, and techniques used in this challenging procedure. Encompassing today's expert knowledge in the field, this medical reference book is an ideal single source for authoritative, up-to-date guidance on every imaginable aspect of liver transplantation.
- Access valuable pearls, pitfalls, and insights from Dr. Ronald Busuttil and Dr. Goran Klintmalm, two of the world's preeminent experts in liver surgery. - Understand today's full range of transplantation techniques with complete step-by-step descriptions of each, and access the background information and management options for each hepatic disease entity. - Take advantage of detailed discussions of everything from pathophysiology and patient and donor selection, to transplantation anesthesia and operative procedures; immunosuppression; postoperative care; and ethical issues.
New to This Edition
- Many new and thoroughly revised chapters include: Deceased Organ Donation after Cardiac and Brain Death; Liver Transplantation for Non-Alcoholic Steatohepatitis; Extended Criteria Donors; Best Techniques for Biliary and Vascular Reconstruction in Living Donor Transplantation; Small for Size Syndrome; Dual Grafts for Transplantation; Arterial Reconstructions-Pitfalls; Transition of Pediatric Patients to Adulthood; Immunosuppressive Biologic Agents; Long Term Toxicity of Immunosuppressive Therapy; Stem Cell and Liver Regeneration; and Extracorporeal Perfusion for Resuscitation of Marginal Grafts. - Stay current in your field and optimize patient outcomes with coverage of the most recent advances in living donor transplantation, pediatric transplantation, and gene and stem cell therapy. - Access the latest information on anti-rejection/immunosuppressive drugs, as well as comprehensive discussions of each drug or combination of drugs used to suppress immune system. - Effortlessly search the entire text online at Expert Consult.
Table of Contents
I: General Considerations 1. History of Liver Transplantation 2. Surgical Anatomy of the Liver 3. Molecular and Cellular Basics of Liver Failure 4. Influence of Transplantation on Liver Surgery 5. Organ Allocation: The US Model 6. Organ Allocation: The European Models 7. Donation After Cardiac or Brain Death: Regulatory and Ethical Principles
II: Patient Evaluation: Adult 8. Current Indications, Contraindications, Delisting Criteria, and Timing for Transplantation 9. Transplantation for Hepatitis A and B 10. Natural History of Hepatitis C 11. Transplantation for Hepatitis C 12. Transplantation for Fulminant Hepatic Failure 13. Transplantation for Primary Biliary Cirrhosis 14. Transplantation for Sclerosing Cholangitis 15. Transplantation for Autoimmune Hepatitis 16. Transplantation for Primary Hepatic Malignancy 17. Transplantation for Cholangiocarcinoma 18. Transplantation for Metastases 19. Transplantation for Hematological Disorders 20. Transplantation for Budd-Chiari Syndrome 21. Transplantation for Alcoholic Liver Disease 22. Transplantation for Nonalcoholic Steatohepatitis 23. Unusual Indications for Transplantation
III: Patient Evaluation: Pediatric 24. General Criteria for Transplantation in Children 25. Transplantation for Cholestatic Liver Disease in Children 26. Transplantation for Biliary Atresia in Children 27. Transplantation for Metabolic Disease in Children 28. Transplantation for Hepatic Malignancy in Children
IV: Special Considerations in Patient Evaluation 29. Ethical Decisions in Transplantation 30. Psychiatric Assessment of Liver Transplant Candidates 31. Pretransplantation Evaluation: Cardiac 32. Pretransplantation Evaluation: Renal 33. Pretransplantation Evaluation: Infectious Disease 34. Role of the Clinical Nurse Coordinator 35. Radiological Evaluation in Transplantation 36. Monitoring and Care 37. Nutritional Aspects of Transplantation in Adults 38. Management of Portal Hypertensive Hemorrhage 39. Portopulmonary Hypertension and Hepatopulmonary Syndrome
V: Operation 40. Donor Selection and Management 41. Extended Criteria Donors 42. Donating After Cardiac Death 43. The Donor Operation 44. Principles of Liver Preservation 45. Recipient Hepatectomy and Grafting 46. Anesthesia for Liver Transplantation
VI: Split and Living Donor Transplantation 47. Imaging Techniques for Partial Grafting 48. Living Donor Transplantation in Children 49. Living Donor Transplantation: Evaluation and Selection in Adults 50. Adult Living Donor Right Hepatectomy and Recipient Operation 51. Adult Living Donor Left Hepatectomy and Recipient Operation 52. Split Liver Transplantation for Pediatric and Adult Recipients 53. Split Liver Transplantation for Two Adult Recipients 54. Biliary and Vascular Reconstruction in Living Donor Transplantation 55. Small-for-Size Syndrome 56. Minimally Invasive Living Donor Hepatectomy 57. Dual Grafts for Transplantation 58. Outcomes of Living Donor Transplantation: The Western Perspective 59. Outcomes of Living Donor Transplantation: The Eastern Perspective 60. Ethics of Living Donor Transplantation
VII: Unusual Operative Problems 61. Arterial Reconstruction Pitfalls 62. Portal Vein Thrombosis and Other Venous Anomalies 63. Combined Liver-Kidney Transplantation 64. Retransplantation 65. Clinical Management of Necrotic Liver Before and After Transplantation 66. Intestinal and Multivisceral Transplantation 67. Transplantation: Situs Inversus and Polysplenia Syndrome 68. Auxiliary Transplantation
VIII: Postoperative Care 69. Postoperative Intensive Care Management in Adults 70. Postoperative Intensive Care Management in Children 71. Postoperative Management Beyond the Intensive Care Unit: Adults 72. Postoperative Care of Pediatric Transplant Recipients 73. Transition of Pediatric Patients to Adulthood 74. Renal Failure in Adults 75. Graft Failure 76. Technical Problems: Biliary 77. Arterial Complications after Transplantation 78. Infections After Transplantation 79. Recurrent Hepatitis C After Transplantation 80. Late Complications and Recurrence of Disease After Transplantation 81. Neuropsychiatric Complications 82. Neurological Complications 83. Role of the Posttransplantation Clinical Nurse Coordinator
IX: Transplant Pathology 84. Histopathology of Liver Transplantation 85. Pathology of NonNeoplastic Disease After Transplantation 86. Transplant-Related Malignancies
X: Immunology of Liver Transplantation 87. Rejection After Transplantation 88. Leukocyte Chimerism- Meaning and Consequences 89. ABO, Tissue Typing, and Crossmatching Incompatibility 90. Graft-Versus-Host Disease
XI: Immunosuppression 91. Induction and Maintenance of Immunosuppression 92. Special Considerations for Immunosuppression In Children 93. Treatment of Acute and Chronic Rejection 94. Novel Immunosuppression of Patients with Hepatic Malignancies 95. Novel Immunosuppressive Drugs 96. Immunosuppressive Biologic Agents 97. Long-term Toxicity of Immunosuppressive Therapy
XII: Survival and Results 98. Outcome Predictors in Transplantation 99. U.S. Trends in Transplantation 100. Long-term Functional Recovery and Quality of Life 101. Survival and Quality of Life in Children
XIII: Future Developments in Liver Transplantation 102. Genetic and Genomic Potentials in Liver Transplantation 103. Liver and Hepatocyte Xenotransplantation 104. Stem Cell and Liver Regeneration 105. Ischemia-Reperfusion Injury in Liver Transplantation 106. Extracorporeal Perfusion for Resuscitation of Marginal Grafts 107. Current Clinical Status of Extracorporeal Devices